The Blues have seen their fine form falter recently and a loss to Mourinho’s men, will see Spurs overtake them into fourth place.
The Portuguese has only lost once since he took over – a 2-1 defeat to another ex-team, Manchester United.
Kick off is 5.30pm West African time.
Tottenham XI vs Chelsea: Gazzaniga, Aurier, Alderweireld, Sanchez, Vertonghen, Dier, Sissoko, Dele, Son, Lucas, Kane
Chelsea XI vs Tottenham: Kepa, Rudiger, Tomori, Zouma, Azpilicueta, Kante, Kovacic, Alonso, Willian, Mount, Abraham
Sunday, December 22